Tomoyoshi Nozaki Selected Research

trifluoromethionine

2/2008	Kinetic characterization of methionine gamma-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound against amoebiasis.
10/2003	Identification and characterization of two isoenzymes of methionine gamma-lyase from Entamoeba histolytica: a key enzyme of sulfur-amino acid degradation in an anaerobic parasitic protist that lacks forward and reverse trans-sulfuration pathways.

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Tomoyoshi Nozaki Research Topics

Disease

17	Amebiasis (Amoebiasis) 01/2022 - 10/2003
6	Infections 01/2022 - 01/2007
6	Malaria 07/2021 - 11/2003
5	Cysts 01/2018 - 12/2008
4	Liver Abscess 01/2022 - 08/2003
3	Amebic Liver Abscess 01/2022 - 01/2004
3	Communicable Diseases (Infectious Diseases) 08/2021 - 11/2009
3	Neoplasms (Cancer) 01/2020 - 02/2008
1	Virus Diseases (Viral Diseases) 01/2022
1	Parasitic Diseases (Parasitic Disease) 12/2021
1	African Trypanosomiasis (Nagana) 01/2021
1	Coccidiosis 12/2020
1	Appendicitis 01/2017
1	Amebic Dysentery (Amoebic Dysentery) 01/2016
1	Persistent Infection 12/2015
1	Encephalitis (Encephalitis, Rasmussen) 02/2015
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2013
1	Reinfection 09/2011
1	Cryptosporidiosis 07/2010
1	Starvation 01/2008
1	Parasitemia 01/2004
1	Dysentery 08/2003
1	Colitis 08/2003

Drug/Important Bio-Agent (IBA)

11	Pharmaceutical PreparationsIBA 01/2022 - 08/2008
6	Metronidazole (Metric)FDA LinkGeneric 01/2022 - 09/2011
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2003
3	Dihydrotachysterol (AT 10)IBA 01/2021 - 01/2004
3	EnzymesIBA 06/2015 - 01/2004
3	Amino Acids FDA Link 12/2010 - 08/2003
3	Methionine (L-Methionine)FDA Link 11/2009 - 10/2003
2	GTP Phosphohydrolases (GTPases)IBA 01/2022 - 01/2021
2	Antimalarials (Antimalarial Agents)IBA 12/2021 - 01/2020
2	pyrimidineIBA 07/2021 - 12/2020
2	Biological ProductsIBA 01/2021 - 06/2015
2	Recombinant ProteinsIBA 01/2019 - 11/2009
2	ParaffinIBA 01/2017 - 02/2015
2	Cysteine (L-Cysteine)FDA Link 01/2016 - 12/2010
2	trifluoromethionineIBA 02/2008 - 10/2003
1	LuciferasesIBA 01/2022
1	RNA Splicing FactorsIBA 01/2022
1	Small Interfering RNA (siRNA)IBA 01/2022
1	Bexarotene (LGD1069)FDA Link 01/2022
1	Alitretinoin FDA Link 01/2022
1	KinesinsIBA 01/2022
1	HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA 08/2021
1	12- (4'- azido- 2'- nitrophenoxy)dodecanoyl- coenzyme AIBA 01/2021
1	Cysteine Proteases (Cysteine Protease)IBA 01/2020
1	Carrier Proteins (Binding Protein)IBA 01/2020
1	HydrolasesIBA 01/2020
1	CytokininsIBA 02/2018
1	thidiazuron (DROPP)IBA 02/2018
1	Virulence Factors (Pathogenicity Factors)IBA 01/2018
1	Formaldehyde (Formol)FDA Link 01/2017
1	Periodic AcidIBA 01/2017
1	DisulfidesIBA 01/2016
1	IronIBA 12/2015
1	Sulfates (Sulfates, Inorganic)IBA 06/2015
1	Culture MediaIBA 06/2015
1	ChloratesIBA 06/2015
1	Serine O-AcetyltransferaseIBA 01/2015
1	Cysteine SynthaseIBA 01/2015
1	Interleukin-8 (Interleukin 8)IBA 01/2014
1	Oxygen (Dioxygen)IBA 01/2012
1	NitrogenIBA 01/2012
1	Phenobarbital (Luminal)FDA Link 09/2011
1	Tinidazole FDA Link 09/2011
1	18S Ribosomal RNAIBA 07/2010
1	DNA (Deoxyribonucleic Acid)IBA 07/2010
1	AmidesIBA 01/2010
1	L-methionine gamma-lyaseIBA 11/2009
1	LyasesIBA 02/2008
1	AntigensIBA 01/2008
1	SulfurIBA 01/2007
1	Diphosphonates (Bisphosphonates)IBA 01/2004
1	PeroxiredoxinsIBA 11/2003
1	propargylglycineIBA 10/2003
1	NucleotidesIBA 08/2003

Therapy/Procedure

3	Therapeutics 03/2016 - 01/2007
1	Appendectomy 01/2017
1	Drug Therapy (Chemotherapy) 01/2015
1	Oral Administration 01/2010
1	Lasers (Laser) 11/2003